A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation

Humanized mice that express the human UDP-glucuronosyltransferase (UGT) 1 locus have been developed in a Ugt1-null background as a model to improve predictions of human UGT1A-dependent drug clearance. Enzyme kinetic parameters (K(m) and V(max)) and pharmacokinetic properties of three probe drugs wer...

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Main Authors: Cai, Hongliang, Nguyen, Nghia, Peterkin, Vincent, Yang, Young-Sun, Hotz, Kathy, Beaton La Placa, Deirdre, Chen, Shujuan, Tukey, Robert H., Stevens, Jeffrey C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872941/
https://ncbi.nlm.nih.gov/pubmed/20124398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.030130
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