A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation

Humanized mice that express the human UDP-glucuronosyltransferase (UGT) 1 locus have been developed in a Ugt1-null background as a model to improve predictions of human UGT1A-dependent drug clearance. Enzyme kinetic parameters (K(m) and V(max)) and pharmacokinetic properties of three probe drugs wer...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Cai, Hongliang, Nguyen, Nghia, Peterkin, Vincent, Yang, Young-Sun, Hotz, Kathy, Beaton La Placa, Deirdre, Chen, Shujuan, Tukey, Robert H., Stevens, Jeffrey C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2010
Ábhair:
Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872941/
https://ncbi.nlm.nih.gov/pubmed/20124398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.030130
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla