Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

Mutations in parkin, a ubiquitin ligase, cause early-onset familial Parkinson's disease (AR-JP). How parkin suppresses Parkinsonism remains unknown. Parkin was recently shown to promote the clearance of impaired mitochondria by autophagy, termed mitophagy. Here, we show that parkin promotes mit...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Lee, Joo-Yong, Nagano, Yoshito, Taylor, J. Paul, Lim, Kah Leong, Yao, Tso-Pang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2010
Onderwerpen:
Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872903/
https://ncbi.nlm.nih.gov/pubmed/20457763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201001039
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items