Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

Mutations in parkin, a ubiquitin ligase, cause early-onset familial Parkinson's disease (AR-JP). How parkin suppresses Parkinsonism remains unknown. Parkin was recently shown to promote the clearance of impaired mitochondria by autophagy, termed mitophagy. Here, we show that parkin promotes mit...

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Autores principales: Lee, Joo-Yong, Nagano, Yoshito, Taylor, J. Paul, Lim, Kah Leong, Yao, Tso-Pang
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872903/
https://ncbi.nlm.nih.gov/pubmed/20457763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201001039
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