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Chromatin dynamics during repair of chromosomal DNA double-strand breaks

The integrity of a eukaryotic genome is often challenged by DNA double-strand breaks (DSBs). Even a single, unrepaired DSB can be a lethal event, or such unrepaired damage can result in chromosomal instability and loss of genetic information. Furthermore, defects in the pathways that respond to and...

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Détails bibliographiques
Auteurs principaux: Sinha, Manisha, Peterson, Craig L
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872485/
https://ncbi.nlm.nih.gov/pubmed/20495614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi.09.22
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