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A minority of foci or pan-nuclear apoptotic staining of γH2AX in the S phase after UV damage contain DNA double-strand breaks

UV irradiation induces histone variant H2AX phosphorylated on serine 139 (γH2AX) foci and high levels of pan-nuclear γH2AX staining without foci, but the significance of this finding is still uncertain. We examined the formation of γH2AX and 53BP1 that coincide at sites of double-strand breaks (DSBs...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: de Feraudy, Sebastien, Revet, Ingrid, Bezrookove, Vladimir, Feeney, Luzviminda, Cleaver, James E.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2010
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872460/
https://ncbi.nlm.nih.gov/pubmed/20351298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002175107
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