Amyloid-β Fibrillogenesis Seeded by Interface-Induced Peptide Misfolding and Self-Assembly

The amphipathicity of the natively unstructured amyloid-β (Aβ40) peptide may play an important role in its aggregation into β-sheet rich fibrils, which is linked to the pathogenesis of Alzheimer's disease. Using the air/subphase interface as a model interface, we characterized Aβ's surface...

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Detalhes bibliográficos
Main Authors: Chi, Eva Y., Frey, Shelli L., Winans, Amy, Lam, Kin Lok H., Kjaer, Kristian, Majewski, Jaroslaw, Lee, Ka Yee C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872264/
https://ncbi.nlm.nih.gov/pubmed/20483339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.01.056
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