Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

R5X4 HIV-1 have impaired utilization of CCR5 on primary CD4+ lymphocytes but the mechanisms responsible are not well defined. Using a panel of diverse R5X4 Envs we identified a spectrum of CCR5 use on CD4+ lymphocytes. Greater lymphocyte CCR5 use correlated with relative resistance to CCR5 mAbs and...

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Hlavní autoři: Loftin, Lamorris M., Kienzle, Martha F., Yi, Yanjie, Lee, Benhur, Lee, Fang-Hua, Gray, Lachlan, Gorry, Paul R., Collman, Ronald G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872044/
https://ncbi.nlm.nih.gov/pubmed/20381825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.03.009
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