Mast Cell-derived Prostaglandin D(2) Controls Hyaluronan Synthesis in Human Orbital Fibroblasts via DP1 Activation: IMPLICATIONS FOR THYROID EYE DISEASE

Thyroid eye disease (TED) is a debilitating disorder characterized by the accumulation of adipocytes and hyaluronan (HA). Production of HA by fibroblasts leads to remarkable increases in tissue volume and to the anterior displacement of the eyes. Prostaglandin D(2) (PGD(2)), mainly produced by mast...

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Detalhes bibliográficos
Main Authors: Guo, Naxin, Baglole, Carolyn J., O'Loughlin, Charles W., Feldon, Steven E., Phipps, Richard P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871447/
https://ncbi.nlm.nih.gov/pubmed/20308056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074534
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