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Mechanisms of Enzymatic Degradation of Amyloid Beta Microfibrils Generating Nanofilaments and Nanospheres Related to Cytotoxicity
Amyloid beta (Aβ) fibrils are found in brain tissue of persons with Alzheimer’s disease (AD), where they accumulate as plaques. One way to reduce Aβ accumulation in the brain and potentially treat AD is with Aβ-degrading enzymes such as Neprilysin (NEP) and Insulin-Degrading Enzyme (IDE). However, e...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871304/ https://ncbi.nlm.nih.gov/pubmed/20196618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902134p |
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