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The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function
Prp19 is a member of the WD40-repeat family of E3 ubiquitin ligases and a conserved eukaryotic RNA splicing factor essential for activation and stabilization of the spliceosome. To understand the role of the WD40 repeat domain of Prp19 we have determined its structure using X-ray crystallography. Th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871033/ https://ncbi.nlm.nih.gov/pubmed/20462492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.02.015 |
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