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Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model

The role of IGF-I in the negative regulation of GH expression and release is demonstrated by in vitro and in vivo models; however, the targets and mechanisms of IGF-I remain unclear. We have developed a cell-specific knockout mouse in which the IGF-I receptor was ablated from the somatotroph in orde...

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Main Authors: Romero, Christopher J., Ng, Yewade, Luque, Raul M., Kineman, Rhonda D., Koch, Linda, Bruning, Jens C., Radovick, Sally
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Endocrine Society 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2870932/
https://ncbi.nlm.nih.gov/pubmed/20211984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0393
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