Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.

Two classes (site 1- and site 2-selective) of cAMP analogs, which either alone or in combination demonstrate a preference for binding to type II rather than type I cAMP-dependent protein kinase isozyme, potently inhibit growth in a spectrum of human cancer cell lines in culture. Treatment of K-562 h...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tortora, G, Clair, T, Katsaros, D, Ally, S, Colamonici, O, Neckers, L M, Tagliaferri, P, Jahnsen, T, Robins, R K, Cho-Chung, Y S
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287016/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2539602/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.8.2849
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