BACE1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: Implication for neuritic plaque development

Neuritic plaques are a pathological hallmark of Alzheimer's disease (AD). However, the origin of extracellular amyloid peptide (Aβ) deposits and the process of plaque development remain poorly understood. The present study attempted to explore plaque pathogenesis by localizing β-secretase-1 (BA...

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Autori principali: Zhang, Xue-Mei, Cai, Yan, Xiong, Kun, Cai, Huaibin, Luo, Xue-Gang, Feng, Jia-Chun, Clough, Richard W., Struble, Robert G., Patrylo, Peter R., Yan, Xiao-Xin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869535/
https://ncbi.nlm.nih.gov/pubmed/20092570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2009.07017.x
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