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Can BACE1 Inhibition Mitigate Early Axonal Pathology in Neurological Diseases?
β-Secretase-1 (BACE1) is the rate-limiting enzyme for the genesis of amyloid-β (Aβ) peptides, the main constituents of the amyloid plaques in the brains of Alzheimer’s disease (AD) patients. BACE1 is being evaluated as an anti-Aβ target for AD therapy. Recent studies indicate that BACE1 elevation is...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3995167/ https://ncbi.nlm.nih.gov/pubmed/24081378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-131400 |
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