Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson’s disease models

α-Synuclein (α-syn) is a small lipid-binding protein involved in vesicle trafficking whose function is poorly characterized. It is of great interest to human biology and medicine because α-syn dysfunction is associated with several neurodegenerative disorders, including Parkinson’s disease (PD). We...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Su, Linhui Julie, Auluck, Pavan K., Outeiro, Tiago Fleming, Yeger-Lotem, Esti, Kritzer, Joshua A., Tardiff, Daniel F., Strathearn, Katherine E., Liu, Fang, Cao, Songsong, Hamamichi, Shusei, Hill, Kathryn J., Caldwell, Kim A., Bell, George W., Fraenkel, Ernest, Cooper, Antony A., Caldwell, Guy A., McCaffery, J. Michael, Rochet, Jean-Christophe, Lindquist, Susan
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Limited 2010
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869493/
https://ncbi.nlm.nih.gov/pubmed/20038714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.004267
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi