Identification of a Mutant PfCRT-Mediated Chloroquine Tolerance Phenotype in Plasmodium falciparum

Mutant forms of the Plasmodium falciparum transporter PfCRT constitute the key determinant of parasite resistance to chloroquine (CQ), the former first-line antimalarial, and are ubiquitous to infections that fail CQ treatment. However, treatment can often be successful in individuals harboring muta...

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Main Authors: Valderramos, Stephanie G., Valderramos, Juan-Carlos, Musset, Lise, Purcell, Lisa A., Mercereau-Puijalon, Odile, Legrand, Eric, Fidock, David A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869323/
https://ncbi.nlm.nih.gov/pubmed/20485514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000887
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