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E17K substitution in AKT1 in prostate cancer
BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)–AKT pathway is activated in many cancers. Mutational hotspots in AKT1 and in the regulatory and catalytic subunits of PI3K have been detected in multiple tumour types. In AKT1, the E17K substitution leads to a PI3K-independent activation of AKT1....
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2869172/ https://ncbi.nlm.nih.gov/pubmed/20407443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605673 |
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