E17K substitution in AKT1 in prostate cancer

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)–AKT pathway is activated in many cancers. Mutational hotspots in AKT1 and in the regulatory and catalytic subunits of PI3K have been detected in multiple tumour types. In AKT1, the E17K substitution leads to a PI3K-independent activation of AKT1....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Boormans, J L, Korsten, H, Ziel-van der Made, A C J, van Leenders, G J L H, Verhagen, P C M S, Trapman, J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2010
Pynciau:
Short Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869172/
https://ncbi.nlm.nih.gov/pubmed/20407443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605673
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