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E17K substitution in AKT1 in prostate cancer

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)–AKT pathway is activated in many cancers. Mutational hotspots in AKT1 and in the regulatory and catalytic subunits of PI3K have been detected in multiple tumour types. In AKT1, the E17K substitution leads to a PI3K-independent activation of AKT1....

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Boormans, J L, Korsten, H, Ziel-van der Made, A C J, van Leenders, G J L H, Verhagen, P C M S, Trapman, J
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869172/
https://ncbi.nlm.nih.gov/pubmed/20407443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605673
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