E17K substitution in AKT1 in prostate cancer

BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)–AKT pathway is activated in many cancers. Mutational hotspots in AKT1 and in the regulatory and catalytic subunits of PI3K have been detected in multiple tumour types. In AKT1, the E17K substitution leads to a PI3K-independent activation of AKT1....

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Main Authors: Boormans, J L, Korsten, H, Ziel-van der Made, A C J, van Leenders, G J L H, Verhagen, P C M S, Trapman, J
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2010
Assuntos:
Short Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869172/
https://ncbi.nlm.nih.gov/pubmed/20407443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605673
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