Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism

OBJECTIVE: To study the impact of the 79A>C polymorphism in the cytidine deaminase (CDA) gene on the pharmacokinetics of gemcitabine and its metabolite 2′,2′-difluorodeoxyuridine (dFdU) in non-small-cell lung cancer (NSCLC) patients. PATIENTS AND METHODS: Patients (n = 20) received gemcitabine 1,...

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Main Authors:	Maring, Jan Gerard, Wachters, Floris M., Slijfer, Monique, Maurer, J. Marina, Boezen, H. Marike, Uges, Donald R. A., de Vries, Elisabeth G. E., Groen, Harry J. M.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer-Verlag 2010
Fag:	Pharmacokinetics and Disposition
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2868996/ https://ncbi.nlm.nih.gov/pubmed/20213492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-010-0799-0
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Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism

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