POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature

The t(8;21)(q22;q22) translocation, present in ~5% of adult acute myeloid leukemia (AML) cases, produces the AML1/ETO fusion protein. Dysregulation of the POU domain-containing transcription factor POU4F1 is a recurring abnormality in t(8;21) AML. Here, we show that POU4F1 over-expression is highly...

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Main Authors: Fortier, Julie M., Payton, Jacqueline E., Cahan, Patrick, Ley, Timothy J., Walter, Matthew J., Graubert, Timothy A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868953/
https://ncbi.nlm.nih.gov/pubmed/20376082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.61
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