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Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications
The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene. This protein has multiple effe...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Hindawi Publishing Corporation
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100545/ https://ncbi.nlm.nih.gov/pubmed/21629739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/104631 |
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