Acute Myeloid Leukemia with the t(8;21) Translocation: Clinical Consequences and Biological Implications

The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene. This protein has multiple effe...

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Autores principales: Reikvam, Håkon, Hatfield, Kimberley Joanne, Kittang, Astrid Olsnes, Hovland, Randi, Bruserud, Øystein
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100545/
https://ncbi.nlm.nih.gov/pubmed/21629739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/104631
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