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POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature
The t(8;21)(q22;q22) translocation, present in ~5% of adult acute myeloid leukemia (AML) cases, produces the AML1/ETO fusion protein. Dysregulation of the POU domain-containing transcription factor POU4F1 is a recurring abnormality in t(8;21) AML. Here, we show that POU4F1 over-expression is highly...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2868953/ https://ncbi.nlm.nih.gov/pubmed/20376082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2010.61 |
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