Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi

The Borrelia burgdorferi Rrp1 protein is a diguanylate cyclase that controls a regulon consisting of ~10% of the total genome. Because Rrp1 lacks a DNA-binding domain, its regulatory capability is most likely mediated through the production of bis-(3′–5′)-cyclic dimeric GMP (c-di-GMP). C-di-GMP bind...

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Hauptverfasser: Freedman, John C., Rogers, Elizabeth A., Kostick, Jessica L., Zhang, Hongming, Iyer, Radha, Schwartz, Ira, Marconi, Richard T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868932/
https://ncbi.nlm.nih.gov/pubmed/20030712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1574-695X.2009.00635.x
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