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The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors.

Midgestation embryos were infected with replication-defective retroviral vectors that either transduced the myc oncogene, the ras oncogene, or both oncogenes simultaneously. The myc virus induced tumors in diverse organs at a very low frequency and with a long latency period, while approximately 20%...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Compere, S J, Baldacci, P, Sharpe, A H, Thompson, T, Land, H, Jaenisch, R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286884/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2648394/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.7.2224
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