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Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease

Neo-Darwinian evolutionary theory is based on exquisite selection of phenotypes caused by small genetic variations, which is the basis of quantitative trait contribution to phenotype and disease. Epigenetics is the study of nonsequence-based changes, such as DNA methylation, heritable during cell di...

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Detalhes bibliográficos
Main Authors: Feinberg, Andrew P., Irizarry, Rafael A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868296/
https://ncbi.nlm.nih.gov/pubmed/20080672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906183107
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