Molecular and Clinical Responses in a Pilot Study of Gefitinib with Paclitaxel and Radiation in Locally Advanced Head and Neck Cancer

PURPOSE: Epidermal growth factor receptor (EGFR) overexpression in head and neck squamous cell carcinoma (HNSCC) stimulates tumor cell proliferation, inhibits apoptosis, and increases chemotherapy and radiation resistance. We examined the toxicity, safety and the effects on EGFR signaling in tumor b...

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Main Authors: Van Waes, Carter, Allen, Clint T., Citrin, Deborah, Gius, David, Colevas, A. Dimetrios, Harold, Nancy A., Rudy, Susan, Nottingham, Liesl, Muir, Christine, Chen, Zhong, Singh, Anurag K., Dancey, Janet, Morris, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868084/
https://ncbi.nlm.nih.gov/pubmed/19879702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.05.037
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