Proteomic Signatures of Epidermal Growth Factor Receptor and Survival Signal Pathways Correspond to Gefitinib Sensitivity in Head and Neck Cancer

PURPOSE: Gefitinib targeting of the epidermal growth factor receptor (EGFR) has shown limited activity in clinical trials of head and neck squamous cell carcinoma (HNSCC). To investigate the underlying molecular mechanism, the proteomic signatures and responses of EGFR and downstream signals have be...

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Publicado no:Clin Cancer Res
Main Authors: Pernas, Francisco G., Allen, Clint T., Winters, Mary E., Yan, Bin, Friedman, Jay, Dabir, Bhavana, Saigal, Kunal, Mundinger, Gerhard S., Xu, Xiaojiang, Morris, John C., Calvo, Katherine R., Van Waes, Carter, Chen, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689817/
https://ncbi.nlm.nih.gov/pubmed/19318490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1011
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