RGS4 is a negative regulator of insulin release from pancreatic β-cells in vitro and in vivo

Therapeutic strategies that augment insulin release from pancreatic β-cells are considered beneficial in the treatment of type 2 diabetes. We previously demonstrated that activation of β-cell M(3) muscarinic receptors (M3Rs) greatly promotes glucose-stimulated insulin secretion (GSIS), suggesting th...

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Autori principali: Ruiz de Azua, Inigo, Scarselli, Marco, Rosemond, Erica, Gautam, Dinesh, Jou, William, Gavrilova, Oksana, Ebert, Philip J., Levitt, Pat, Wess, Jürgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867926/
https://ncbi.nlm.nih.gov/pubmed/20385802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003655107
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