EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to cellular toxicity and decay in various human disorders including Alzheimer’s and Parkinson’s disease. Recently, we demonstrated that the polyphenol (-)-epi-gallocatechine gallate (EGCG) inhibits α-synuclein...

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Hlavní autoři: Bieschke, Jan, Russ, Jenny, Friedrich, Ralf P., Ehrnhoefer, Dagmar E., Wobst, Heike, Neugebauer, Katja, Wanker, Erich E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867908/
https://ncbi.nlm.nih.gov/pubmed/20385841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910723107
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