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Loss of phosphoinositide 3-kinase γ decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis

BACKGROUND: Phosphoinositide 3-kinase γ (PI3Kγ) has been depicted as a major regulator of inflammatory processes, including leukocyte activation and migration towards several chemokines. This study aims to explore the role of PI3Kγ in the murine model of antigen-induced arthritis (AIA). METHODS: Dev...

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Detalhes bibliográficos
Main Authors: Gruen, Michael, Rose, Christina, König, Christian, Gajda, Mieczyslaw, Wetzker, Reinhard, Bräuer, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867834/
https://ncbi.nlm.nih.gov/pubmed/20374644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-11-63
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