Dynamic O-GlcNAc cycling at promoters of Caenorhabditis elegans genes regulating longevity, stress, and immunity

Nutrient-driven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene expression in metazoans. The global effects of GlcNAcylation on transcription can be addressed directly in C. elegans because knockouts of the O-GlcNAc cycling enzymes are viable and fer...

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Autori principali: Love, Dona C., Ghosh, Salil, Mondoux, Michelle A., Fukushige, Tetsunari, Wang, Peng, Wilson, Mark A., Iser, Wendy B., Wolkow, Catherine A., Krause, Michael W., Hanover, John A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867743/
https://ncbi.nlm.nih.gov/pubmed/20368426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911857107
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