PET Imaging of Leptin Biodistribution and Metabolism in Rodents and Primates

Here we report the first PET imaging studies of leptin's systemic biodistribution in vivo. PET imaging using (18)F and (68)Ga labeled leptin revealed that in mouse the hormone was rapidly taken up by megalin (gp330/LRP2), a multiligand endocytic receptor localized in renal tubules. In addition,...

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Hlavní autoři: Ceccarini, Giovanni, Flavell, Robert R, Butelman, Eduardo R, Synan, Michael, Willnow, Thomas E, Bar-Dagan, Maya, Goldsmith, Stanley J, Kreek, Mary J, Kothari, Paresh, Vallabhajosula, Shankar, Muir, Tom W, Friedman, Jeffrey M
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867490/
https://ncbi.nlm.nih.gov/pubmed/19656493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.07.001
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