PET Imaging of Leptin Biodistribution and Metabolism in Rodents and Primates

Here we report the first PET imaging studies of leptin's systemic biodistribution in vivo. PET imaging using (18)F and (68)Ga labeled leptin revealed that in mouse the hormone was rapidly taken up by megalin (gp330/LRP2), a multiligand endocytic receptor localized in renal tubules. In addition,...

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Bibliographic Details
Main Authors:	Ceccarini, Giovanni, Flavell, Robert R, Butelman, Eduardo R, Synan, Michael, Willnow, Thomas E, Bar-Dagan, Maya, Goldsmith, Stanley J, Kreek, Mary J, Kothari, Paresh, Vallabhajosula, Shankar, Muir, Tom W, Friedman, Jeffrey M
Format:	Artigo
Language:	Inglês
Published:	2009
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2867490/ https://ncbi.nlm.nih.gov/pubmed/19656493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.07.001
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PET Imaging of Leptin Biodistribution and Metabolism in Rodents and Primates

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