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Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs

The Similarity Ensemble Approach (SEA) relates proteins based on the set-wise chemical similarity among their ligands. It can be used to rapidly search large compound databases and to build cross-target similarity maps. The emerging maps relate targets in ways that reveal relationships one might not...

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Detalhes bibliográficos
Main Authors: DeGraw, Amanda J., Keiser, Michael J., Ochocki, Joshua D., Shoichet, Brian K., Distefano, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867455/
https://ncbi.nlm.nih.gov/pubmed/20180535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901613f
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