Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

The roles of autoimmune regulator (Aire)–expressing medullary thymic epithelial cells (mTECs) in the organization of the thymic microenvironment for establishing self-tolerance are enigmatic. We sought to monitor the production and maintenance of Aire-expressing mTECs by a fate-mapping strategy in w...

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Autores principales: Nishikawa, Yumiko, Hirota, Fumiko, Yano, Masashi, Kitajima, Hiroyuki, Miyazaki, Jun-ichi, Kawamoto, Hiroshi, Mouri, Yasuhiro, Matsumoto, Mitsuru
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2010
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867289/
https://ncbi.nlm.nih.gov/pubmed/20404099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092144
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