Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity rema...

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Main Authors: Niki, Shino, Oshikawa, Kiyotaka, Mouri, Yasuhiro, Hirota, Fumiko, Matsushima, Akemi, Yano, Masashi, Han, Hongwei, Bando, Yoshimi, Izumi, Keisuke, Matsumoto, Masaki, Nakayama, Keiichi I., Kuroda, Noriyuki, Matsumoto, Mitsuru
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440703/
https://ncbi.nlm.nih.gov/pubmed/16628255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26971
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