Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation

Molecular paradigms underlying the death of hematopoietic stem cells (HSCs) induced by ionizing radiation are poorly defined. We have examined the role of Puma (p53 up-regulated mediator of apoptosis) in apoptosis of HSCs after radiation injury. In the absence of Puma, HSCs were highly resistant to...

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Autors principals: Yu, Hui, Shen, Hongmei, Yuan, Youzhong, XuFeng, Richard, Hu, Xiaoxia, Garrison, Sean P., Zhang, Lin, Yu, Jian, Zambetti, Gerard P., Cheng, Tao
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867261/
https://ncbi.nlm.nih.gov/pubmed/20177048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-248278
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