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Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose γ-irradiation
Molecular paradigms underlying the death of hematopoietic stem cells (HSCs) induced by ionizing radiation are poorly defined. We have examined the role of Puma (p53 up-regulated mediator of apoptosis) in apoptosis of HSCs after radiation injury. In the absence of Puma, HSCs were highly resistant to...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867261/ https://ncbi.nlm.nih.gov/pubmed/20177048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-248278 |
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