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Gene-specific repression of the p53 target gene PUMA via intragenic CTCF–Cohesin binding
The p53 transcriptional program orchestrates alternative responses to stress, including cell cycle arrest and apoptosis, but the mechanism of cell fate choice upon p53 activation is not fully understood. Here we report that PUMA (p53 up-regulated modulator of apoptosis), a key mediator of p53-depend...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867207/ https://ncbi.nlm.nih.gov/pubmed/20478995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1881010 |
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