Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function

Normal cardiac function requires dynamic modulation of contraction. β(1) adrenergic-induced protein kinase A (PKA) phosphorylation of cardiac myosin binding protein C (cMyBP-C) may regulate crossbridge kinetics to modulate contraction. We tested this idea with mechanical measurements and echocardiog...

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Main Authors: Tong, Carl W., Stelzer, Julian E., Greaser, Marion L., Powers, Patricia A., Moss, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867079/
https://ncbi.nlm.nih.gov/pubmed/18802026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.177683
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