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Structural insights into the molecular mechanism of H-NOX activation

Nitric oxide (NO) signaling in mammals controls important processes such as smooth muscle relaxation and neurotransmission by the activation of soluble guanylate cyclase (sGC). NO binding to the heme domain of sGC leads to dissociation of the iron–histidine (Fe–His) bond, which is required for enzym...

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Detalhes bibliográficos
Main Authors: Olea, Charles, Herzik, Mark A, Kuriyan, John, Marletta, Michael A
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867026/
https://ncbi.nlm.nih.gov/pubmed/20162612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.357
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