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Structural insights into the molecular mechanism of H-NOX activation

Nitric oxide (NO) signaling in mammals controls important processes such as smooth muscle relaxation and neurotransmission by the activation of soluble guanylate cyclase (sGC). NO binding to the heme domain of sGC leads to dissociation of the iron–histidine (Fe–His) bond, which is required for enzym...

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Détails bibliographiques
Auteurs principaux: Olea, Charles, Herzik, Mark A, Kuriyan, John, Marletta, Michael A
Format: Artigo
Langue:Inglês
Publié: Wiley Subscription Services, Inc., A Wiley Company 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867026/
https://ncbi.nlm.nih.gov/pubmed/20162612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.357
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