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Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain

Interior topological features, such as pockets and channels, have evolved in proteins to regulate biological functions by facilitating the diffusion of biomolecules. Decades of research using the globins as model heme proteins have clearly highlighted the importance of gas pockets around the heme in...

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Detalhes bibliográficos
Main Authors: Winter, Michael B., Herzik, Mark A., Kuriyan, John, Marletta, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203760/
https://ncbi.nlm.nih.gov/pubmed/21997213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114038108
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