Structural basis for unfolding pathway-dependent stability of proteins: Vectorial unfolding versus global unfolding

Point mutations in proteins can have different effects on protein stability depending on the mechanism of unfolding. In the most interesting case of I27, the Ig-like module of the muscle protein titin, one point mutation (Y9P) yields opposite effects on protein stability during denaturant-induced “g...

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Detalhes bibliográficos
Main Authors: Yagawa, Keisuke, Yamano, Koji, Oguro, Takaomi, Maeda, Masahiro, Sato, Takehiro, Momose, Takaki, Kawano, Shin, Endo, Toshiya
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867010/
https://ncbi.nlm.nih.gov/pubmed/20095049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.346
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