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Highly attenuated vaccinia virus mutants for the generation of safe recombinant viruses.

An attenuated vaccinia virus mutant with specific genetic lesions has been used to develop a vehicle for safer live recombinant virus vaccines. The mutant virus 48-7 has an 8-MDa deletion starting 2.2 MDa from the left end of the viral genome and point mutations in the gene encoding the 14-kDa fusio...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Rodriguez, D, Rodriguez, J R, Rodriguez, J F, Trauber, D, Esteban, M
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 1989
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286673/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784004/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.4.1287
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