Highly attenuated vaccinia virus mutants for the generation of safe recombinant viruses.

An attenuated vaccinia virus mutant with specific genetic lesions has been used to develop a vehicle for safer live recombinant virus vaccines. The mutant virus 48-7 has an 8-MDa deletion starting 2.2 MDa from the left end of the viral genome and point mutations in the gene encoding the 14-kDa fusio...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Rodriguez, D, Rodriguez, J R, Rodriguez, J F, Trauber, D, Esteban, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286673/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.4.1287
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