Highly attenuated vaccinia virus mutants for the generation of safe recombinant viruses.
An attenuated vaccinia virus mutant with specific genetic lesions has been used to develop a vehicle for safer live recombinant virus vaccines. The mutant virus 48-7 has an 8-MDa deletion starting 2.2 MDa from the left end of the viral genome and point mutations in the gene encoding the 14-kDa fusio...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1989
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286673/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2784004/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.4.1287 |
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