Organophosphorus Pesticides Decrease M2 Muscarinic Receptor Function in Guinea Pig Airway Nerves via Indirect Mechanisms

BACKGROUND: Epidemiological studies link organophosphorus pesticide (OP) exposures to asthma, and we have shown that the OPs chlorpyrifos, diazinon and parathion cause airway hyperreactivity in guinea pigs 24 hr after a single subcutaneous injection. OP-induced airway hyperreactivity involves M2 mus...

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Bibliografiske detaljer
Main Authors: Proskocil, Becky J., Bruun, Donald A., Thompson, Charles M., Fryer, Allison D., Lein, Pamela J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866713/
https://ncbi.nlm.nih.gov/pubmed/20479945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010562
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