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The Outer Vestibule of the Na(+) Channel–Toxin Receptor and Modulator of Permeation as Well as Gating
The outer vestibule of voltage-gated Na(+) channels is formed by extracellular loops connecting the S5 and S6 segments of all four domains (“P-loops”), which fold back into the membrane. Classically, this structure has been implicated in the control of ion permeation and in toxin blockage. However,...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Molecular Diversity Preservation International
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866490/ https://ncbi.nlm.nih.gov/pubmed/20479982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md8041373 |
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