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Negative regulation of the deacetylase SIRT1 by DBC1
SIRT1 is an NAD-dependent deacetylase critically involved in stress responses, cellular metabolism and, possibly, ageing1–15. The tumour suppressor p53 represents the first non-histone substrate functionally regulated by acetylation and deacetylation16,17; we and others previously found that SIRT1 p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866287/ https://ncbi.nlm.nih.gov/pubmed/18235502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06515 |
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