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Mcl-1–Bim complexes accommodate surprising point mutations via minor structural changes
Mcl-1 is an antiapoptotic Bcl-2-family protein that protects cells against death. Structures of Mcl-1, and of other anti-apoptotic Bcl-2 proteins, reveal a surface groove into which the α-helical BH3 regions of certain proapoptotic proteins can bind. Despite high overall structural conservation, dif...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866276/ https://ncbi.nlm.nih.gov/pubmed/20066663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.329 |
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